Fellowbook News

A urine test for lung cancer? Nanosensors make it possible

Harvard and MIT researchers teamed up to develop a novel screening test that could identify lung cancer a lot earlier and easier than current methods. The test detects lung cancer using nanoprobes, which send out reporter molecules that are picked up on urine analysis. This breakthrough, which is more sensitive than CT and delivers on a proof-of-concept experiment originally proposed in 2017, was recently detailed in a study published in Science Translational Medicine.

“What if you had a detector that was so small that it could circulate in your body, find the tumor all by itself, and send a signal to the outside world?” asked lead author Sangeeta Bhatia, MD, PhD, at a 2016 TED Talk. “It sounds a little like science fiction. But actually, nanotechnology allows us to do just that… Continue reading.

Synthetic Biology and Tissue Engineering Grow Liver Tissue In-Body
Damage to the liver in patients developing end-stage liver disease has become too severe for the organ’s normally extraordinary regenerative capacity to repair or compensate for that damage. Once this point of no return has been reached the only option...
Circadian rhythms can influence drugs’ effectiveness
MIT researchers find circadian variations in liver function play an important role in how drugs are broken down in the body. Giving drugs at different times of day could significantly affect how they are metabolized in the liver, according to a new study...
Inhalable sensors could enable early lung cancer detection
The diagnostic, which requires only a simple urine test to read the results, could make lung cancer screening more accessible worldwide. Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors...
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics
Synthetic biomarkers, bioengineered sensors that generate molecular reporters in diseased microenvironments, represent an emerging paradigm in precision diagnostics. Despite the utility of DNA barcodes as a multiplexing tool, their susceptibility to nucleases...
Tissue model reveals key players in liver regeneration
By tracing the steps of liver regrowth, MIT engineers hope to harness the liver’s regenerative abilities to help treat chronic disease. The human liver has amazing regeneration capabilities: Even if up to 70 percent of it is removed, the remaining tissue...