Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.
“Protein A chromatography is robust and works well, but it’s also expensive and can create significant supply chain problems because you have to produce the Protein A and immobilize it on a resin,” says Andrew Zydney, PhD, professor of chemical engineering at Pennsylvania State University. “Our hope is that, by moving away from Protein A, we open up opportunities that are higher throughput and lower cost… Continue reading.