The tumor microenvironment, which includes epithelial, immune and connective tissue cells, plays important roles in the pathogenesis of colorectal tumors.
Few studies have examined how the microenvironment changes as colorectal tumors transition from advanced adenomas to pre-invasive carcinomas. Ken Lau, PhD, and colleagues have now used single-cell RNA-sequencing, multiplex immunofluorescence imaging, and computational approaches to explore the colonic tumor microenvironment in mouse models of advanced adenoma (APC) and pre-invasive inflammation-induced cancer (AOM/DSS)… Continue reading.