Acute myeloid leukemia (AML) is a particularly aggressive disease that develops when cells in the bone marrow turn into cancerous blood cells. Even when chemotherapy or other treatments kill leukemic cells circulating in the blood, the cancerous stem cells can linger in the bone marrow, enabling the disease to re-emerge.
With support of internal seed funding, an interdisciplinary team of chemists, biomedical engineers, and basic scientists at the University of Rochester report progress in targeting and destroying these leukemic stem cells with a modified form of micheliolide, a natural product found in plants of the magnolia family… Continue reading.